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Environmental presence of heavy metal Heavy metals are present in the environment as a result of both naturally occurring pedogenetic processes and human activities such as mining, smelting, electroplating, pesticide use, release of biosolids and phosphate fertilizer (Dixit et al., 2015)

Bustos AY, Font de Valdez G, Fadda S, Taranto MP (2018) New insights into bacterial bile resistance mechanisms: the role of bile salt hydrolase and its impact on human health

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doi: 10.1016/j.bbrc.2003.08.105 160 AnandPKunnumakkaraABNewmanRAAggarwalBB

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It can either promote cell death via regulation of Ca 2+ ion level and cABL kinase activity or activate tumor growth through the transcription factors STAT5A (signal transducer and activator of transcription 5A) and CREB (cAMP response element-binding protein)